Academic Appointment
Assistant Professor
Research Focus
Women's HealthOvarian DisordersEndometriosis CancersGenetics
Degrees / Designations

PhD

Mailing Address

2660 Oak Street
OVCARE, Robert HN Ho Research Centre
Vancouver BC
Canada

Biography

Dr. Michael Anglesio is a principal investigator in the Ovarian Cancer Research Program and Women's Health Research Institute (WHRI) as well as an assistant professor in the Department of Obstetrics and Gynecology at the University of British Columbia. After studying microbiology and immunology at McGill University, he completed his PhD at the Pediatric Cancer Research Program and post-doctoral fellowship at the Peter MacCallum Cancer Center in Melbourne, Australia. His work focuses on further refining and differentiating ovarian cancer subtypes and the various origins of these subtypes. He has also taken a strong interest in understanding how malignancies arise from uterine tissues and is developing model systems to better understand how clear cell and endometrioid ovarian cancers differentiate as they arise from endometriosis.

 

Applicants:

Our research group is currently looking for graduate students in the MSc stream with potential for progression to PhD.

(N03.2023) Graduate Students (MSc/PhD) – to take on genomic and biomarker centric research on endometriosis. Optimal candidates will have experience with PCR based methods, sequencing, next-generation sequencing, and/or IHC. Candidates should have a working knowledge of female anatomy and physiology, especially around uterine and ovarian biology. Experience with histopathology and recognizing different cell types under a microscope is highly beneficial. Candidates should have strong grades in statistics. Candidates must have a strong work ethic, and be able to work independently (problem solve) and be effective in a dynamic team environment.

(PA01.2023) Graduate Student (MSc) – to take on a novel project examining molecular changes associated with uterine aging. The candidate should have experience with PCR based methods, sequencing, next-generation sequencing. Knowledge of female reproductive biology is an asset, as is familiarity with medical/pathology nomenclature and terminology. In addition to molecular analysis, the candidate will work with other groups to analyze health care records and health services utilization. Candidates should have strong grades in statistics. Candidates must have a strong work ethic, and be able to work independently (problem solve) and be effective in a dynamic team environment.

Application that are not relevant to our research group, and applicants that do not apply for advertised position, may not receive a reply. For graduate trainee applicants please keep in mind application deadlines are many months in advance of study start dates. See more information at the Women+ and Children’s Health Sciences (WACH) program web site https://wach.med.ubc.ca/

News and Awards

Honing in on precision treatments for endometriosis

Mar 14, 2023

Narrowing in on why endometriosis can lead to cancer

Mar 3, 2018

Publications

  • The Journal of pathology -

    Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8{{sup}}+{{/sup}} TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas.

    Heinze K, Nazeran TM, Lee S, Krämer P, Cairns ES, Chiu DS, Leung SC, Kang EY, Meagher NS, Kennedy CJ, Boros J, Kommoss F, Vollert HW, Heitz F, du Bois A, Harter P, Grube M, Kraemer B, Staebler A, Kommoss FK, Heublein S, Sinn HP, Singh N, Laslavic A, Elishaev E, Olawaiye A, Moysich K, Modugno F, Sharma R, Brand AH, Harnett PR, DeFazio A, Fortner RT, Lubinski J, Lener M, Tołoczko-Grabarek A, Cybulski C, Gronwald H, Gronwald J, Coulson P, El-Bahrawy MA, Jones ME, Schoemaker MJ, Swerdlow AJ, Gorringe KL, Campbell I, Cook L, Gayther SA, Carney ME, Shvetsov YB, Hernandez BY, Wilkens LR, Goodman MT, Mateoiu C, Linder A, Sundfeldt K, Kelemen LE, Gentry-Maharaj A, Widschwendter M, Menon U, Bolton KL, Alsop J, Shah M, Jimenez-Linan M, Pharoah PD, Brenton JD, Cushing-Haugen KL, Harris HR, Doherty JA, Gilks B, Ghatage P, Huntsman DG, Nelson GS, Tinker AV, Lee CH, Goode EL, Nelson BH, Ramus SJ, Kommoss S, Talhouk A, Köbel M, Anglesio MS
  • Reproductive sciences (Thousand Oaks, Calif.) -

    Somatic Genomic Events in Endometriosis: Review of the Literature and Approach to Phenotyping.

    Yong PJ, Talhouk A, Anglesio MS
  • Clinical cancer research : an official journal of the American Association for Cancer Research -

    Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma.

    Krämer P, Talhouk A, Brett MA, Chiu DS, Cairns ES, Scheunhage DA, Hammond RFL, Farnell D, Nazeran TM, Grube M, Xia Z, Senz J, Leung S, Feil L, Pasternak J, Dixon K, Hartkopf A, Krämer B, Brucker S, Heitz F, du Bois A, Harter P, Kommoss FKF, Sinn HP, Heublein S, Kommoss F, Vollert HW, Manchanda R, de Kroon CD, Nijman HW, de Bruyn M, Thompson EF, Bashashati A, McAlpine JN, Singh N, Tinker AV, Staebler A, Bosse T, Kommoss S, Köbel M, Anglesio MS
  • The New England journal of medicine -

    Cancer-Associated Mutations in Endometriosis without Cancer.

    Anglesio MS, Papadopoulos N, Ayhan A, Nazeran TM, Noë M, Horlings HM, Lum A, Jones S, Senz J, Seckin T, Ho J, Wu RC, Lac V, Ogawa H, Tessier-Cloutier B, Alhassan R, Wang A, Wang Y, Cohen JD, Wong F, Hasanovic A, Orr N, Zhang M, Popoli M, McMahon W, Wood LD, Mattox A, Allaire C, Segars J, Williams C, Tomasetti C, Boyd N, Kinzler KW, Gilks CB, Diaz L, Wang TL, Vogelstein B, Yong PJ, Huntsman DG, Shih IM
  • Clinical cancer research : an official journal of the American Association for Cancer Research -

    Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).

    Talhouk A, George J, Wang C, Budden T, Tan TZ, Chiu DS, Kommoss S, Leong HS, Chen S, Intermaggio MP, Gilks B, Nazeran TM, Volchek M, Elatre W, Bentley RC, Senz J, Lum A, Chow V, Sudderuddin H, Mackenzie R, Leong SCY, Liu G, Johnson D, Chen B, Group A, Alsop J, Banerjee SN, Behrens S, Bodelon C, Brand AH, Brinton L, Carney ME, Chiew YE, Cushing-Haugen KL, Cybulski C, Ennis D, Fereday S, Fortner RT, García-Donas J, Gentry-Maharaj A, Glasspool R, Goranova T, Greene CS, Haluska P, Harris HR, Hendley J, Hernandez BY, Herpel E, Jimenez-Linan M, Karpinskyj C, Kaufmann SH, Keeney GL, Kennedy CJ, Köbel M, Koziak JM, Larson MC, Lester J, Lewsley LA, Lissowska J, Lubiński J, Luk H, Macintyre G, Mahner S, McNeish IA, Menkiszak J, Nevins N, Osorio A, Oszurek O, Palacios J, Hinsley S, Pearce CL, Pike MC, Piskorz AM, Ray-Coquard I, Rhenius V, Rodriguez-Antona C, Sharma R, Sherman ME, De Silva D, Singh N, Sinn P, Slamon D, Song H, Steed H, Stronach EA, Thompson PJ, Tołoczko A, Trabert B, Traficante N, Tseng CC, Widschwendter M, Wilkens LR, Winham SJ, Winterhoff B, Beeghly-Fadiel A, Benitez J, Berchuck A, Brenton JD, Brown R, Chang-Claude J, Chenevix-Trench G, deFazio A, Fasching PA, García MJ, Gayther SA, Goodman MT, Gronwald J, Henderson MJ, Karlan BY, Kelemen LE, Menon U, Orsulic S, Pharoah PDP, Wentzensen N, Wu AH, Schildkraut JM, Rossing MA, Konecny GE, Huntsman DG, Huang RY, Goode EL, Ramus SJ, Doherty JA, Bowtell DD, Anglesio MS
  • Gynecologic oncology -

    Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival.

    Brieger KK, Peterson S, Lee AW, Mukherjee B, Bakulski KM, Alimujiang A, Anton-Culver H, Anglesio MS, Bandera EV, Berchuck A, Bowtell DDL, Chenevix-Trench G, Cho KR, Cramer DW, DeFazio A, Doherty JA, Fortner RT, Garsed DW, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Harris HR, Høgdall E, Huntsman DG, Shen H, Jensen A, Johnatty SE, Jordan SJ, Kjaer SK, Kupryjanczyk J, Lambrechts D, McLean K, Menon U, Modugno F, Moysich K, Ness R, Ramus SJ, Richardson J, Risch H, Rossing MA, Trabert B, Wentzensen N, Ziogas A, Terry KL, Wu AH, Hanley GE, Pharoah P, Webb PM, Pike MC, Pearce CL,
  • Clinical obstetrics and gynecology -

    Endometriosis-associated Ovarian Cancers.

    Anglesio MS, Yong PJ
  • Histopathology -

    Identical TP53 mutations provide evidence that late-recurring tubo-ovarian high-grade serous carcinomas do not represent new peritoneal primaries.

    Anglesio MS, O'Neill CJ, Senz J, Gilks CB, McCluggage WG
  • Nature genetics -

    Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.

    Wang YK, Bashashati A, Anglesio MS, Cochrane DR, Grewal DS, Ha G, McPherson A, Horlings HM, Senz J, Prentice LM, Karnezis AN, Lai D, Aniba MR, Zhang AW, Shumansky K, Siu C, Wan A, McConechy MK, Li-Chang H, Tone A, Provencher D, de Ladurantaye M, Fleury H, Okamoto A, Yanagida S, Yanaihara N, Saito M, Mungall AJ, Moore R, Marra MA, Gilks CB, Mes-Masson AM, McAlpine JN, Aparicio S, Huntsman DG, Shah SP
  • PloS one -

    Single-Patient Molecular Testing with NanoString nCounter Data Using a Reference-Based Strategy for Batch Effect Correction.

    Talhouk A, Kommoss S, Mackenzie R, Cheung M, Leung S, Chiu DS, Kalloger SE, Huntsman DG, Chen S, Intermaggio M, Gronwald J, Chan FC, Ramus SJ, Steidl C, Scott DW, Anglesio MS
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