Immune System

The purpose of this study is to collect biospecimens (fecal, urine, blood, oral swab) and clinical data to serve as a resource for future research on Parkinson’s disease and other movement disorders. The careful collection, storage and retrieval of biospecimens and medical information for research projects are critical for improving understanding of healthy development and disease mechanisms and the subsequent development of effective treatments. Biospecimens from this biobank will be made available for ethically-approved studies.

The purpose of this study is to evaluate the immune response and safety of a new vaccine in preventing diseases due to infection with respiratory syncytial virus (RSV). This RSV vaccine will be tested in older adults who are recipients of lung or kidney transplants and are at an increased risk of RSV compared to healthy older adults. 

The purpose of this study is to assess the efficacy of two dose levels of brepocitinib in adults with dermatomyositis compared to a placebo. After 52 weeks of double-blind treatment, participants have the option to continue therapy in a 52-week, open-label extension phase where all participants will receive brepocitinib.

The purpose of this study is to test the ability of a new immune modulator, QBKPN, to boost natural immunity to improve health, including reducing respiratory infections. It will also measure the effect of QBKPN on non-respiratory infections, quality of life and overall survival.

The purpose of this study is to characterize a recipient's immune system response to kidney transplantation to uncover an immune signature of early graft rejection.

The purpose of this study is to establish a protocol for improved human leukocyte antigen (HLA) matching for renal transplant patients.

The purpose of the study is to investigate the safety and efficacy of itolizumab versus placebo in individuals with acute graft-versus-host disease, when combined with corticosteroids as a first line treatment.