Blood, Heart and Circulation

The purpose of this study is to evaluate evogliptin for aortic stenosis (AS). AS is caused by progressive thickening and calcification of the aortic valve leaflets which leads to a reduction in aortic valve opening. Valve replacement is currently the only known treatment for this condition once it becomes severe enough to cause symptoms. No treatment has been found to date that can delay the progression of this disease.

The purpose of this study is to investigate the safety and effectiveness of non-invasive transcutaneous spinal cord stimulation (TSCS) in conjunction with conventional rehabilitation in helping with the recovery of bladder function in persons with spinal cord injury (SCI). The study team will assess immediate TSCS efficacy when the stimulation is turned on, as well as the persisting effects of TSCS (e.g. any changes in function) that remain after the stimulation is turned off and after several weeks of regular stimulation.

The purpose of this study is to identify gaps in health services and make recommendations for the development of high-quality and equitable systems of stroke care informed by young women stroke survivors' experiences.

To participate in this study, complete the online form.

The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics of study drug AZD3427 in addition to standard of care in participants with heart failure and pulmonary hypertension due to left heart disease (World Health Organization Group 2).

The purpose of this study is to understand and document the experiences of patients who live at least 60 minutes outside of the Lower Mainland and who are traveling to Vancouver for a solid organ transplant. The research team aims to document the psychological, social, emotional and cultural impact for patients leaving their communities to access care in Vancouver. The study will also capture the associated out-of-pocket costs that these transplant patients incur before, during and after the transplant operation.

The purpose of this study is to determine the normal levels of oxygen in tissues for healthy people using near-infrared spectroscopy (NIRS); find out how oxygen levels differ in various parts of the body for healthy individuals; and gather information and analyze data from 107 participants to get a diverse range of perspectives.

If you are interested in participating in the study, please book a visit online.

The purpose of this study is to collect biospecimens (fecal, urine, blood, oral swab) and clinical data to serve as a resource for future research on Parkinson’s disease and other movement disorders. The careful collection, storage and retrieval of biospecimens and medical information for research projects are critical for improving understanding of healthy development and disease mechanisms and the subsequent development of effective treatments. Biospecimens from this biobank will be made available for ethically-approved studies.

The purpose of this study is to test the comparative effectiveness of two types of cardiac resynchronization therapy (CRT) lead implantations (His vs LBBP) in relation to patient-centered outcomes (e.g. quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g. lead dislodgement, infection) relative to standard of care biventricular pacing.

The purpose of this study is to investigate the effects of non-invasive transcutaneous spinal cord stimulation (TCSCS) on cardiovascular, bladder, bowel and sexual function in people with spinal cord injury. The study team is interested in the immediate, long-term and longer-term effects (eight weeks after cessation of therapy) of non-invasive stimulation on these functions.

The purpose of this study is to explore the differences in socioeconomic and demographic factors between clinical trial participants and non-participants, and to explore whether clinical trial participation influences overall clinical outcomes. This is a retrospective chart review that will collect sociodemographic and economic factors of all multiple myeloma patients and identify differences between clinical trial participants and non-participants, as well as analyze whether clinical trial participation influenced clinical outcomes of these patients.

The purpose of this study is to test a potential new medicine, NNC6019-0001, for people who have heart disease due to transthyretin (TTR) amyloidosis. The study will compare the new medicine at two dose levels (10 mg/kg and 60 mg/kg) to placebo on change in a 6-minute walk test and N-terminal pro-brain natriuretic peptide (NT-proBNP) test from baseline to week 52, or occurrence of death or cardiovascular hospitalization, in participants with hereditary transthyretin amyloidosis or wild-type transthyretin amyloid cardiomyopathy.

The purpose of this study is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor. The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias or incident heart failure.

The purpose of this study is to compare the standard of care therapy (VRd + Rd therapy) and CAR-T therapy (VRd + CAR-T) for newly diagnosed multiple myeloma patients who do not plan to receive hematopoietic stem cell transplant as initial therapy.

The purpose of this study is to collect real-world data on the safety and efficacy of the MANTA vascular closure device using ultrasound guidance in stopping blood flow/close catheter access sites at the end of large-bore interventional cardiology procedures compared to using pre-procedural depth locator measurements.

The purpose of this study is to determine if the use of colchicine, a drug that reduces inflammation, can lower the risk of having a stroke or heart attack from blood clots compared to placebo, and improve recovery in people with a recent brain bleed.

The purpose of this study is to determine whether a 6-month course of oral micronised purified flavonoid fraction (MPFF), compared with placebo, improves the symptoms and signs of post-thrombotic syndrome (PTS) and quality of life at six months follow-up.

The purpose of this study is to collect information to determine if some ablation strategies work better than others for treating atrial fibrillation.

The purpose of this study is to support an indication of inclisiran for the reduction of cardiovascular risk in participants with established atherosclerotic cardiovascular disease who have elevated low-density lipoprotein cholesterol levels despite being on a background of well-tolerated dose of a high-intensity statin therapy. 

The purpose of this study is to optimize the treatment of asciminib in patients with chronic myelogenous leukemia in chronic phase (CML-CP), who have previously been treated with at least 2 tyrosine kinase inhibitors. Additionally, this study will investigate the usage of two different dosing regimes of asciminib, 80mg daily and 40mg twice daily.

The purpose of this study is to compare standard treatment against a newly approved medication for patients presenting to the emergency department with a heart condition called atrial fibrillation. A sub-study will also look at a new consenting process in the emergency department and the experience of patients with this consent process.