The purpose of this study is to investigate whether rocatinlimab is safe and effective in reducing asthma symptoms (such as an asthma exacerbation, also known as an asthma attack) and improving lung function, as well as whether it causes any side effects.
The purpose of this study is to understand and document the experiences of patients who live at least 60 minutes outside of the Lower Mainland and who are traveling to Vancouver for a solid organ transplant. The research team aims to document the psychological, social, emotional and cultural impact for patients leaving their communities to access care in Vancouver. The study will also capture the associated out-of-pocket costs that these transplant patients incur before, during and after the transplant operation.
The purpose of this study is to evaluate dexpramipexole as an add-on therapy in participants with inadequately controlled eosinophilic asthma, on Global Initiative for Asthma (GINA) 2021 Step 3, 4 or 5 therapy (or GINA 2021 Step 4 or 5 therapy in Poland) to confirm improvements in lung function, asthma control and quality of life.
The purpose of this study is to investigate the safety, tolerability and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma.
The purpose of this study is to help the study sponsor determine whether adding the study drug, belumosudil, to usual treatment (immunosuppression per transplant site and azithromycin) is better, the same or worse than the usual treatment approach alone for chronic lung rejection.
The purpose of this study is to evaluate the efficacy and safety of selnoflast compared with placebo in participants with asthma.
The purpose of this study is to evaluate the effect of three dosing regimens of povorcitinib on pulmonary function in people with inadequately controlled moderate-to-severe asthma.
The purpose of this study is to evaluate the immune response and safety of a new vaccine in preventing diseases due to infection with respiratory syncytial virus (RSV). This RSV vaccine will be tested in older adults who are recipients of lung or kidney transplants and are at an increased risk of RSV compared to healthy older adults.
The purpose of this study is to learn more about the study drug, dupilumab, when given over a longer duration in patients with moderate-to-severe asthma that is not well controlled. The study will investigate if the study drug can prevent loss in lung function and improve asthma symptoms and quality of life by looking at whether the study drug works when taken for three years.
The purpose of this study is to test the ability of a new immune modulator, QBKPN, to boost natural immunity to improve health, including reducing respiratory infections. It will also measure the effect of QBKPN on non-respiratory infections, quality of life and overall survival.
The purpose of this project is to engage Indigenous peoples with respiratory conditions to understand their experiences living with respiratory conditions; to explore Indigenous peoples’ healthcare experiences; and to identify promising practices that can improve the treatment experiences and outcomes among Indigenous peoples with respiratory conditions.
The purpose of this study is to determine if Alpha Lipoic Acid (ALA) reduces inflammation and oxidative stress markers in the blood, as well as
improved blood vessel function in patients with moderate to severe obstructive sleep apnea (OSA).
The purpose of this study is to build a tool to support medical decision-making and the integration of a validated clinical-prediction model into routine care for individuals with chronic obstructive pulmonary disease (COPD).
The purpose of this study is to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.
The purpose of this study is to determine the lung and immune function benefits of stopping vaping for 72 hours in young adults who use e-cigarettes containing nicotine. The study also aims to determine if telling participants of their own personalized changes to their lung and immune function following the 72 hour abstinence period affects their motivation in quitting vaping.
This randomized controlled trial will enrol patients with acute severe brain injury who pass a spontaneous breathing trial but have decreased level of consciousness. It will directly compare (1) prompt extubation vs. (2) prompt tracheostomy vs. (3) usual care, with extubation or tracheostomy timed according to physicians' discretion. The primary outcome will be ICU free days (days spent alive and outside an ICU).
People who may be at increased risk of lung cancer due to age and smoking history will be invited to participate in this international study to determine the best way of using computed tomography (CT) of the chest to screen for early lung cancer. Overseas data show that CT screening (screening tests can find diseases early, when they're easier to treat) can reduce deaths from lung cancer and this study will help determine who is most likely benefit from screening.
Sleep Apnea (SA) is a disorder that causes pauses in breathing during sleep that expose the heart to oxygen deprivation. It is common in patients with heart failure (HF) where it is associated with increased risk of hospitalizations and death. It is not known however whether treating SA reduces these risks. This study is looking at whether a respiratory device known as Adaptive Servo Ventilation (ASV) can reduce the rate of cardiovascular hospitalizations and death in subjects with HF and SA.
The purpose of this study is to evaluate the safety, tolerability and effectiveness of rilzabrutinib (also known as SAR444671) compared to a placebo in adults with moderate-to-severe asthma.
The purpose of this study is to understand asthmatic patients' knowledge, perceptions and viewpoints about using a telehealth approach to manage their asthma conditions.