The purpose of this study is to extend our understanding of the factors that oncology care providers consider when making decisions about cancer treatment and care for adults who are structurally vulnerable, and to gain knowledge about the potential impacts of these decisions on clients who are accessing cancer care services.
The purpose of this study is to determine whether lymphatic surgery provides better quality of life compared to only conservative therapy for patients with breast cancer-related lymphedema.
The purpose of this study is to determine whether an oral vitamin called nicotinamide can help prevent skin cancer in 396 high-risk kidney, liver, heart and lung transplant recipients. Participants will be involved in the study for four years and will visit the study doctor or clinical research staff every 17 weeks. Participants will receive nicotinamide or a placebo, taken orally for the entire follow-up period, which will last up to 208 weeks.
The purpose of this study is to explore the differences in socioeconomic and demographic factors between clinical trial participants and non-participants, and to explore whether clinical trial participation influences overall clinical outcomes. This is a retrospective chart review that will collect sociodemographic and economic factors of all multiple myeloma patients and identify differences between clinical trial participants and non-participants, as well as analyze whether clinical trial participation influenced clinical outcomes of these patients.
The purpose of this study is to assess if the study drug, camizestrant, improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+/HER2- early breast cancer with intermediate-high or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy).
The purpose of this study is to investigate risk factors, screening tools and intervention methods that could help provide early diagnosis or prevention of uterine cancer. The study will evaluate how or if these screening and intervention methods are understood, accepted and completed by postmenopausal participants. The ultimate goal is to identify people at high risk for developing endometrial (uterine) cancer through various screening techniques and then tailor an approach to reduce risk through a program of lifestyle interventions.
The purpose of this study is to test a potential new medicine, NNC6019-0001, for people who have heart disease due to transthyretin (TTR) amyloidosis. The study will compare the new medicine at two dose levels (10 mg/kg and 60 mg/kg) to placebo on change in a 6-minute walk test and N-terminal pro-brain natriuretic peptide (NT-proBNP) test from baseline to week 52, or occurrence of death or cardiovascular hospitalization, in participants with hereditary transthyretin amyloidosis or wild-type transthyretin amyloid cardiomyopathy.
The purpose of this study is to determine if metformin can stop changes in the mouth that are related to pre-cancer growths such as oral leukoplakia (white patches) or erythroplakia (red patches) or cancer of the mouth. The study will compare the safety and effects of metformin with the safety and effects of placebo on people’s risk of developing cancer of the mouth.
Vulvar cancer is uncommon and has been neglected in research and clinical trials. In recent years, researchers have learned that the most common type of vulvar cancer, vulvar squamous cell carcinoma (VSCC), develops from pre-cancerous lesions via different pathways. Currently, a "one-size-fits-all" treatment approach is used for VSCC. The aim of this study is to see if personalizing surgical therapy for patients with vulvar cancer based on HPV and TP53 status will improve outcomes.
The purpose of this study is to evaluate the safety, efficacy and tolerability of subcutaneous (SC) blinatumomab for treatment of acute lymphoblastic leukemia and to determine the maximum tolerated dose and preliminary recommended phase 2 dose(s) of SC administered blinatumomab.
The purpose of this study is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor. The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias or incident heart failure.
The purpose of this study is to compare the standard of care therapy (VRd + Rd therapy) and CAR-T therapy (VRd + CAR-T) for newly diagnosed multiple myeloma patients who do not plan to receive hematopoietic stem cell transplant as initial therapy.
The purpose of this study is to optimize the treatment of asciminib in patients with chronic myelogenous leukemia in chronic phase (CML-CP), who have previously been treated with at least 2 tyrosine kinase inhibitors. Additionally, this study will investigate the usage of two different dosing regimes of asciminib, 80mg daily and 40mg twice daily.
The purpose of this study is to identify inheritable mutations among male breast cancer participants by performing genetic testing on their cancer samples, instead of blood samples (such as tumour testing). This testing will allow researchers to identify inheritable mutations when blood samples are not available. This study will evaluate the clinical utility and the feasibility of offering the tumour testing in newly diagnosed male breast cancer patients.
The purpose of this study is to evaluate the effect of a peer navigation program for men with prostate and a peer navigator training course called the True North Peer Navigation program. The study will evaluate patient outcomes such as their ability to take a more active role in their health, quality of life, social support and use of health care services, in addition to the experiences of patients and peer navigators and the factors that make it easier or harder for people to deliver the program to patients in different settings.
The purpose of this study is to understand how to assess for shoulder and arm problems women may experience related to breast cancer and its treatment and to help women know when it may be appropriate to seek physiotherapy care.
The purpose of this study is to evaluate the safety and efficacy of CC-97540 CAR-T cell treatment for subjects with relapsed or refractory B-cell non-Hodgkin lymphoma.
The purpose of this study is to compare the efficacy of the drugs ponatinib versus imatinib, administered as first-line therapy in combination with reduced-intensity chemotherapy, in participants with newly diagnosed Ph+ ALL, as measured by the minimal residual disease (MRD)-negative complete remission (CR) at the end of induction.
The purpose of this study is to evaluate the impact of an aerobic exercise intervention on Chemotherapy-Related Cognitive Changes (CRCC) in women diagnosed with breast cancer who undergo chemotherapy.
The purpose of the study is to test the safety and efficacy of a drug known as CC-220 in combination with other treatments for multiple myeloma patients.